Sitzung vom 9. Januar 1905

vom 14 . 9 . 2009

Biol. Pharm. Bull. 29(9) 1900—1905 (2006)

of normal tissue development in the fetus and cell replacement in certain adult tissues. In contrast to swelling and membrane rupture associated with necrosis, apoptotic cells shrink and maintain their membrane integrity. The hallmarks of apoptosis include cell shrinkage, membrane blebbing, chromatin condensation, and DNA fragmentation. Apoptotic cells are phagocytosed by neighboring cells, eff...

Dmd059121 1890..1905

Subcutaneous injection is an important route of administration for therapeutic proteins that provides several advantages over other modes of parenteral delivery. Despite extensive clinical use, the exact mechanism underlying subcutaneous absorption of proteins is not completely understood, and the accuracy of prediction of absorption of biotherapeutics in humans remains unsatisfactory. This rev...

Dmd065763 1905..1916

Montelukast has been recommended as a selective in vitro and in vivo probe of cytochrome P450 (P450) CYP2C8 activity, but its selectivity toward this enzyme remains unclear. We performed detailed characterization of montelukast metabolism in vitro using human liver microsomes (HLMs), expressed P450s, and uridine 59-diphospho-glucuronosyltransferases (UGTs). Kinetic and inhibition experiments pe...

Phoebus A. Levene, 1905